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Chauhan, A.
- Endometriosis: Clinical Experience of 500 Patients from India
Abstract Views :259 |
PDF Views:0
Authors
T. Bendigeri
1,
N. Warty
2,
R. Sawant
2,
P. Dasmahapatra
3,
K. Padte
4,
A. Humane
5,
A. Chauhan
6,
S. Begum
6,
S. Khan
1,
R. Gajbhiye
1
Affiliations
1 Department of Clinical Research, National Institute for Research in Reproductive Health, Indian Council of Medical Research, J. M. Street, Parel, Mumbai 400 012, IN
2 Sanjivani Diagnostic Centre and General Maternity Home, Alaknanda apartment, Dattani Park, Kandivali (East), Mumbai 400101, IN
3 Spectrum clinic & Endoscopy Research Institute, 6A & 6F Neelamber, 28B, Shakespeare Sarani Kolkata 700 017, West Bengal, IN
4 Dr Kedar's Maternity, Infertility and Surgical Hospital, Endoscopy and IVF Center, Aakash Bhavan, 2nd Floor, Opposite Mathias Plaza, Above Mapusa Urban Co-op Bank, Panji, 403 001, Goa, IN
5 Department of Obstetrics & Gynecology, Government Medical College, Nagpur, Maharashtra 440009, IN
6 Additional professor and Unit Head, Department of Obstetrics and Gynecology, Seth GS Medical College and King Edward Memorial (KEM) Hospital, Mumbai 400012, IN
1 Department of Clinical Research, National Institute for Research in Reproductive Health, Indian Council of Medical Research, J. M. Street, Parel, Mumbai 400 012, IN
2 Sanjivani Diagnostic Centre and General Maternity Home, Alaknanda apartment, Dattani Park, Kandivali (East), Mumbai 400101, IN
3 Spectrum clinic & Endoscopy Research Institute, 6A & 6F Neelamber, 28B, Shakespeare Sarani Kolkata 700 017, West Bengal, IN
4 Dr Kedar's Maternity, Infertility and Surgical Hospital, Endoscopy and IVF Center, Aakash Bhavan, 2nd Floor, Opposite Mathias Plaza, Above Mapusa Urban Co-op Bank, Panji, 403 001, Goa, IN
5 Department of Obstetrics & Gynecology, Government Medical College, Nagpur, Maharashtra 440009, IN
6 Additional professor and Unit Head, Department of Obstetrics and Gynecology, Seth GS Medical College and King Edward Memorial (KEM) Hospital, Mumbai 400012, IN
Source
The Indian Practitioner, Vol 68, No 7 (2015), Pagination: 34-40Abstract
Background/Purpose of Study: Endometriosis, a common, chronic, gynecological condition, has a burden of around 176 million women globally and ∼26 million women alone in India. It is associated with chronic pelvic pain, subfertility, dysmenorrhea and dyspareunia. Information about clinical phenotype of endometriosis is lacking in India. Additionally, the correlation between the symptoms and different characteristics of endometriosis has not been estimated in the Indian population yet. In the present study, we aimed to investigate the clinical phenotype of women with endometriosis and to describe the unusual cases of endometriosis.Methods: Clinical phenotype of endometriosis was studied in a total of 500 women with endometriosis.
Results: Out of 500 cases, 87 (15%) of endometriosis cases were classified as Peritoneal, 291 (58%) as ovarian and 122 (24%) were having deep infiltrating endometriosis (DIE/RV). The disease was classified into Stage I-II (n=183) and Stage III-IV (n=317) as per the revised American Society for Reproductive Medicine (rASRM). In the cohort of women with endometriosis, 77% women experienced dysmenorrhea, 23% dyspareunia, 34% chronic pelvic pain and 14% suffered from dyschezia. Around 13% women had family history of endometriosis. Sixty six percent women either had primary or secondary infertility and 33% had history of miscarriage. We also detected endometriosis having unusual presentation such as endometriosis associated endometrioid type of ovarian cancer, cervical endometriosis, endometriosis associated with didelphys uterus.
Conclusion: The incidence of endometriosis is rising in India and hence there is a need to develop uniform guidelines for the diagnosis and management of endometriosis.
Keywords
Endometriosis, Dysmenorrhea, Chronic Pelvic Pain, Dyspareunia, Dyschezia.
- Development and Validation of HPTLC Method for the Estimation of Ondansetron Hydrochloride in Bulk Drug and Tablet Dosage Forms
Abstract Views :195 |
PDF Views:92
Authors
A. Chauhan
1,
P. K. Arora
2,
A. Yadav
2,
R. M. Singh
2,
D. K. Sharma
2,
S. C. Mathur
2,
G. N. Singh
2
Affiliations
1 Indian Pharmacopoeial Laboratory, Indian Pharmacopoeia Commission, Ministry of Health & Family Welfare, Govt, of India, Sector -23, Rajnagar, Ghaziabad - 201002, IN
2 Indian Pharmacopoeial Laboratory, Indian Pharmacopoeia Commission, Ministry of Health & Family Welfare, Govt, of India, Sector -23, Rajnagar, Ghaziabad- 201002, IN
1 Indian Pharmacopoeial Laboratory, Indian Pharmacopoeia Commission, Ministry of Health & Family Welfare, Govt, of India, Sector -23, Rajnagar, Ghaziabad - 201002, IN
2 Indian Pharmacopoeial Laboratory, Indian Pharmacopoeia Commission, Ministry of Health & Family Welfare, Govt, of India, Sector -23, Rajnagar, Ghaziabad- 201002, IN
Source
Journal of Pharmaceutical Research, Vol 12, No 2 (2013), Pagination: 61-65Abstract
A simple, selective, precise and sensitive high performance thin-layer chromatographic (HPTLC) method has been developed and validated for the analysis of ondansetron hydrochloride both in bulk drug and in tablet dosage forms. The separation was performed on pre-coated silica gel 60 GF254 plates using methanol:triethylamine:glacial acetic acid (9.5:0.5:0.1, v/v/v) as mobile phase. Densitometric analysis was performed in reflectance-absorbance mode at 309 nm. The linear regression analysis data for the calibration plot showed good linear relationship with R2 = 0.998 ± 0.00047 in the range of 300-1100 ng spot-1. The minimum amount of ondansetron hydrochloride that could be detected and quantified was 54.60 and 165.46 ng spot-1 respectively. The mean retardation factor (Rf) for ondansetron hydrochloride was found to be 0.77 ± 0.01. The developed method was validated according to International Conference on Harmonization (ICH) guidelines for specificity, linearity, range, accuracy, precision, detection limit, quantitation limit and robustness etc.Keywords
Ondansetron Hydrochloride, HPTLC, Method Validation.Full Text
- Screening and Diagnosis of Gestational Diabetes Mellitus
Abstract Views :221 |
PDF Views:2
Authors
A. Chauhan
1,
K. Kale
1
Affiliations
1 Department of Obstetrics and Gynecology, Seth GS Medical College and KEM Hospital, Mumbai, IN
1 Department of Obstetrics and Gynecology, Seth GS Medical College and KEM Hospital, Mumbai, IN
Source
The Indian Practitioner, Vol 70, No 7 (2017), Pagination: 16-21Abstract
Women with history of gestational diabetes mellitus (GDM) are at several folds increased risk of developing type 2 DM, metabolic syndrome, coronary artery disease and stroke. Off springs could also become susceptible to various health issues. Early diagnosis and timely management is very important. Therefore screening and diagnosis of pregnant women for GDM is essential. There are various screening tests and controversies exist as to which is the best method for diagnosis. According to this article the single step screening-cum-diagnostic test recommended by Diabetes in Pregnancy Study Group in India (DIPSI) appears to be the most feasible, economical and evidence based, particularly for high risk Indian population.References
- American Diabetes Association. Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 2011 Jan; 34(Suppl 1): S62–S69.
- Hunt KJ, Schuller KL. The increasing prevalence of diabetes in pregnancy. Obstet Gynecol Clin North Am. 2007; 32(2):173-vii.
- Alfadhli EM. Gestational diabetes mellitus. Saudi Med J.2015;36(4):399-406.
- Buchanan TA, Xiang AH, Page KA. Gestational diabetes mellitus: Risks and management during and after pregnancy. Nat Rev Endocrinol. 2012;8(11):639-49.
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- International Association of Diabetes and Pregnancy Study Groups Consensus Panel. International association of diabetes and pregnancy study groups recommendations on the diagnostic and classification of hyperglycemia in pregnancy. Diabetes Care. 2010;33:676–682.
- The World Health Organization guideline 2013. Diagnostic criteria and classification of hyperglycemia first detected in pregnancy. Available: http:// apps.who.int/iris/bitstream/10665/85975/1/WHO_ NMH_MND_13.2_eng.pdf.
- Seshiah V, SahayBK, DasAK, ShahS, Banerjee S, Rao PV, et al. Gestational Diabetes Mellitus- Indian guidelines. J Indian Med Assoc. 2009;107(11):799-802, 804-6